About half of the patients also took oral medication commonly used in the treatment of post-herpetic neuralgia. The extent of use of concomitant medication was similar in the two treatment groups. It should be applied only to intact skin. Cases of methemoglobinemia have been reported in association with local anesthetic use.
Although all patients are at risk for methemoglobinemia, patients with glucosephosphate dehydrogenase deficiency, congenital or idiopathic methemoglobinemia, cardiac or pulmonary compromise, infants under 6 months of age, and concurrent exposure to oxidizing agents or their metabolites are more susceptible to developing clinical manifestations of the condition.
If local anesthetics must be used in these patients, close monitoring for symptoms and signs of methemoglobinemia is recommended. Methemoglobin levels may continue to rise; therefore, immediate treatment is required to avert more serious central nervous system and cardiovascular adverse effects, including seizures, coma, arrhythmias, and death.
Depending on the severity of the signs and symptoms, patients may respond to supportive care, i. A more severe clinical presentation may require treatment with methylene blue, exchange transfusion, or hyperbaric oxygen.
The blood concentration of lidocaine is determined by the rate of systemic absorption and elimination. Longer duration of application, application of more than the recommended number of patches, smaller patients, or impaired elimination may all contribute to increasing the blood concentration of lidocaine.
Hepatic Disease Patients with severe hepatic disease are at greater risk of developing toxic blood concentrations of lidocaine, because of their inability to metabolize lidocaine normally. Non-intact Skin Application to broken or inflamed skin, although not tested, may result in higher blood concentrations of lidocaine from increased absorption.
If eye contact occurs, immediately wash out the eye with water or saline and protect the eye until sensation returns.
Inform patients that use of local anesthetics may cause methemoglobinemia, a serious condition that must be treated promptly. Advise patients or caregivers to stop use and seek immediate medical attention if they or someone in their care experience the following signs or symptoms: pale, gray, or blue colored skin cyanosis ; headache; rapid heart rate; shortness of breath; lightheadedness; or fatigue.
Patients who are administered local anesthetics are at increased risk of developing methemoglobinemia when concurrently exposed to the following drugs, which could include other local anesthetics:. Examples of Drugs Associated with Methemoglobinemia:. Carcinogenesis A minor metabolite, 2, 6-xylidine, has been found to be carcinogenic in rats.
Following are the common side effects:. A localized allergic reaction marked by swelling and redness is perhaps the most common side effect. A highly-possible negative effect is either a poor outcome or a good result lasting only for a very short duration.
When taken through an injection, the drug has some more risks such as spinal fluid leak and an infection. It is an indication of caution if you suddenly experience convulsions, uneven heartbeats, or reduced breathing.
In this case, you must immediately contact your doctor, as you need emergency treatment. These side effects are usually the result of a lidocaine overdose.
Anyways, it is vital to consult your doctor prior to using lidocaine in any form for healing any muscle or back pain. Doing so will ensure that it is likely to be a safer option for you, as the probability of an allergic reaction or an adverse drug interaction is reduced significantly. The program combines a simple exercise program with powerful home remedies that resolve the root causes of sciatica…reduce pain fast…and prevent it from returning.
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Although not all of these side effects may occur, if they do occur they may need medical attention. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:.
Other side effects not listed may also occur in some patients. Do not apply a double dose to make up for a missed one. Lidocaine transdermal may cause other side effects.
Call your doctor if you have any unusual problems while using this medication. Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture not in the bathroom. Do not store patches and topical systems outside the sealed envelope. Fold used patches or topical systems so that the adhesive side sticks to itself and then safely discard into trash and where children and pets cannot get to them.
It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily.
To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of their sight and reach. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them.
However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. If you wear too many lidocaine transdermal patches or topical systems or wear them for too long, too much lidocaine may be absorbed into your blood.
In that case, you may experience symptoms of an overdose. In case of overdose, call the poison control helpline at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at Do not let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription. It is important for you to keep a written list of all of the prescription and nonprescription over-the-counter medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements.
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